Vitellogenin as a multigene family. Not all Xenopus vitellogenin genes may be in an “expressible” configuration.
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چکیده
منابع مشابه
Vitellogenin as a Multigene Family
DNA-cDNA titrations suggest that the Xenopus genome comprises two albumin genes, whereas there are 12 to 16 vitellogenin-like genes. Both sets of genes are expressed in liver, those coding for albumin constitutively, but vitellogenin only when induced by estrogen in both male and female frogs. Mild micrococcal nuclease digestion of liver nuclei to separate “expressed” from “unexpressed” gene fr...
متن کاملLinkage arrangement in the vitellogenin gene family of Xenopus laevis as revealed by gene segregation analysis.
Using restriction fragment length polymorphism (RFLP) we have analyzed the segregation of alleles of the different vitellogenin genes of Xenopus laevis. The results demonstrate that the four genes whose expression is controlled by oestrogen, form two linkage groups. The genes A1, A2 and B1 are linked genetically whereas the fourth gene, the gene B2, segregates independently. The possible origin...
متن کاملStructural analysis of the three vitellogenin genes in Drosophila melanogaster.
Genomic fragments coding for sequences expressed as abundant mRNA in female Drosophila melanogaster were isolated from a lambda library. Hybridization of these clones to polytene chromosomes. in situ, identified four which mapped to X chromosomal region 9A to 9B, the locus for yolk proteins 1 and 2 (Ypl,2) and two which mapped to 12A6-7 to 12D3, the locus for Yp3. These clones were mapped with ...
متن کاملSequestered and Injected Vitellogenin
Vitellogenin (1, 2) is a sex-limited phosphoprotein secreted by the liver in Xenopus females (3, 4) and selectively transferred via the circulatory system to growing oocytes, within which it is converted into the yolk proteins lipovitellin and phosvitin (3, 5, 6) . Selective uptake (7) and conversion (8) of vitellogenin can also take place in isolated oocytes . The available evidence indicates ...
متن کاملAn unusual lysosome compartment involved in vitellogenin endocytosis by Xenopus oocytes
We have investigated the lysosomal compartment of Xenopus oocytes to determine the possible role of this organelle in the endocytic pathway of the yolk protein precursor, vitellogenin. Oocytes have lysosome-like organelles of unusual enzymatic composition at all stages of their development, and the amount of hydrolase activity increases steadily throughout oogenesis. These unusual lysosomes app...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1980
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)43631-9